Endocrine Abstracts

Introduction: Lack of clinically relevant experimental models of human prostate cancer hampers evaluation of novel therapeutic agents. Currently, androgen deprivation therapy is the gold standard treatment for advanced prostate cancer, but inevitably cells survive and repopulate the tumour. Castrate-resistant cells are critical therapeutic targets for more effective treatments but current model systems cannot determine when they arise in disease progression and are unable to r...

Objective: QT interval prolongation of unknown aetiology is common in Turner syndrome (TS). This study set out to explore the presence of known pathogenic long QT (LQT) mutations in TS and to examine the corrected QT interval (QTc) over time and relate the findings to the TS phenotype.Methods: Adult females with TS (n=102) were examined thrice with a mean follow-up of 4.7±0.5 years, and 68 age-matched healthy controls were examined once. QT...

Introduction: The presence of brown adipose tissue (BAT) in humans has recently been demonstrated by histology and positron emission tomography (PET). In previous reports, BAT in adults is primarily confined to the upper chest and neck. Here, we report a case of massive BAT infiltration of the visceral adipose tissue in a patient with catecholamine secreting paraganglioma.Methods: The patient was evaluated with [18F]-FDG PET/CT at three occasi...

Introduction: To investigate whether the incidence of severe hypoglycaemia in pregnant women with type 1 diabetes can be reduced without deteriorating pregnancy outcomes in a routine care setting.Methods/design: A new cohort (2009–2011) of 59 women receiving intensified education about the risk of severe hypoglycaemia in pregnancy was compared with an old cohort (2004–2006) of 108 women. The women entered the study at median 8 (range 5–13)...

Introduction: Patients who do not develop overt hypothyroidism after hemithyroidectomy for benign euthyroid goiter have permanently increased serum levels of TSH and decreased levels of thyroid hormones within the reference ranges. Thyroid hormones are major regulators of mitochondrial function, and the mitochondrial membrane potential (MMP) can be measured by flow cytometry analysis of living cells as the fluorescence intensity of stained peripheral mononuclear blood cells (M...

Objectives: Hypothyroid patients report a diversity of symptoms at disease presentation. We studied how useful symptoms are to predict hypothyroidism, and if this may vary between subgroups of patients.Methods: Patients newly diagnosed with overt autoimmune hypothyroidism (n=140) were prospectively identified in a population by linkage to diagnostic laboratory databases, and we concomitantly enrolled individually sex and age-region matched contr...

Background: Serum IGFI measurements are used during GH replacement in GHDA for titration of the GH dose, to monitor compliance and to avoid overdosing, but it is uncertain if pretreatment IGFI is a determinant of the GH dose or the response to GH treatment.Methods: Data from the NordiNet IOS have been analyzed to determine pretreatment serum IGFI concentrations in GHDA and to analyze if they influence the GH starting dose and/or the therapeutic response ...

Background: Data from several clinical studies have demonstrated the benefit of GH treatment in relation to bone mineral density and body composition in young adults who received GH treatment in childhood due to GHD1–3. There are recommendations to use a higher GH dose in the transition phase compared to the GH dose required during adulthood to mimic the endogenous GH secretion4,5.Methods: Data from NordiNet IOS have been analy...

Background: High levels of mannose-binding lectin (MBL), an activator of complement, have been associated with increased mortality and risk of albuminuria in patients with type 2 diabetes. It is not known if MBL is synthesized in human adipose tissue and the effects of weight loss and changes in insulin sensitivity on MBL levels have been poorly elucidated.Methods: Of 36 nondiabetic obese subjects received a very low-calorie diet (VLCD) of 800 kcal/day f...

Study objective: To study blood pressure (BP) levels and aortic dimensions in women with Turner syndrome (TS).Materials and methods: 102 women with TS (mean age 37.7 years; 18–62 years). 24 hour ambulatory BP measurement and echocardiography was performed on participants.Results: Mean BP systolic (sys) and diastolic (dia) values were (±SD): sysBPday 128.0±15.3; diaBPday 81.6±11.8; sysBPnight 110.4...